Refereed publications

2021 (submitted/preprint) 

[33] Zhao K, Oualkacha K, Lakhal-Chaieb L, Labbe A, Klein K, Shao X, Bernatsky S, Hudson M, Colmegna I, Pastinen T, Zhang T, Daley D,  Greenwood CMT (2021). Detecting differentially methylated regions in bisulfite sequencing data using quasi-binomial mixed models with smooth covariate effect estimates. preprint.

[32] Anzarmou Y, Mkhadri A, Oualkacha K (2021). The Kendall Interaction Filter for Variable Interaction Screening in Ultra High Dimensional Classification Problems. Submitted.

[31] Mohamed Ouhourane, Yi Yang, Andréa Lessa Benedet, Karim Oualkacha (2021). Group Penalized Smooth Quantile Regression. 1-35. Submitted.

[30] Amadou Diogo Barry, Karim Oualkacha, Arthur Charpentier (2021). Weighted asymmetric least squares regression for longitudinal data using GEE. 1-37. Submitted.

2021 (published/in press

[29] Catherine Schramm, Sébastien Jacquemont, Karim Oualkacha, Aurélie Labbe, Celia MT Greenwood (2021). KSPM: A Package For Kernel Semi-Parametric Models. The R Journal. in press. pdf


[28] Zhao K, Oualkacha K, Lakhal‐Chaieb L, Labbe A, Klein K, Ciampi A, Hudson M, Colmegna I, Pastinen T, Zhang T, Daley D, Greenwood CMT (2020), A novel statistical method for modeling covariate effects in bisulfite sequencing derived measures of DNA methylation. Biometrics. doi:10.1111/biom.13307. pdf

[27] Bhatnagar SR, Yi Y, Lu T, Schurr E, Loredo-Osti JC, Forest M, Oualkacha K, Greenwood CMT (2020). Simultaneous SNP selection and adjustment for population structure in high dimensional prediction models. Plos Genetics16(5): e1008766. pdf


[26] Fodé Tounkara, Geneviève Lefebvre, Celia MT Greenwood and Karim Oualkacha (2019). A flexible copula-based approach for the analysis of secondary phenotypes in ascertained samples. Statistics in Medicine. 39: 517-543.

[25] Rachid Kharoubi, Karim Oualkacha, Abdallah Mkhadri (2019). The Cluster Correlation-Network Support Vector Machine for High-dimensional Binary Classification. Journal of Statistical Computation and Simulation. 89:6, 1020-1043, http://DOI: 10.1080/00949655.2019.1575382

[24] Lai Jiang, Karim Oualkacha, Vanessa Didelez, Antonio Ciampi, Pedro Rosa, Andréa L. Benedet, Sulantha Mathotaarachchi, J. Brent Richards, and Celia M.T. Greenwood (2019). Constrained Instruments and their Application to Mendelian Randomization with Pleiotropy. Genetic Epidemiology.


[23] Sun J, Oualkacha K, Greenwood CMT, Lakhal-Chaieb L (2018). Multivariate association test for rare variants controlling for cryptic and family relatedness. Canadian Journal of Statistics. 47: 90-107

[22] D’Souza Y, Ferradji A, Saw CL, Oualkacha K, Richard L, Popradi G and Sapir-Pichhadze R. (2018). Inaccuracies in epitope repertoire estimations when using multilocus allele-level HLA genotype imputation tools. HLA: Immune Response Genetics.

[21] Sun J, Oualkacha K, Forgetta V, Zheng HF, Richards B, Orwoll E,  Evans D, Greenwood CMT, (2018). Exome-wide rare variant analyses of two bone mineral density phenotypes: the challenges of analyzing rare genetic variation. Scientific Reports, Volume 8, Issue 1: 220.

[20] Auerbach J, Howey R, Jiang L, Justice A, Li L, Oualkacha K, Sayols-Baixeras S, Aslibekyan SW (2018). Causal modeling in a multi-omics setting: insights from Genetic Analysis Workshop 20. BMC Genetics. 19 (Suppl 1) :74.

[19] Zhao K, Jiang L, Klein K, Greenwood CMT, Oualkacha K. (2018). CpG-set association assessment of lipid concentration changes and DNA methylation on chromosome 11. BMC Proceeding. 12 (Suppl 9) :30.

[18] Jiang L, Zhao K, Klein K, Canty AJ, Oualkacha K, Greenwood CMT. (2018). Investigating potential causal relationships between SNPs, DNA methylation and HDL. BMC Proceeding.  12 (Suppl 9) :20.


[17] Lakhal-Chaieb L, Greenwood CMT, Ouhourane M, Zhao K, Abdous B,  Oualkacha K. (2017). A smoothed EM-algorithm for DNA methylation profiles from sequencing-based methods in cell lines or for a single cell type. Statistical Applications in Genetics and Molecular Biology. 16(5-6):333-347. doi: 10.1515/sagmb-2016-0062.

[16] Ferradji A, D’Souza Y, Saw CL, Oualkacha K, Richard L, Sapir-Pichhadze R. (2017). Performance of an allele-level multi-locus HLA genotype imputation tool in hematopoietic stem cell donors from Quebec. Immun Inflamm Dis., doi: 10.1002/iid3.185

[15] Lajoie M, Drouin S, Caron M, St-Onge P, Ouimet M, Gioia R, Lafond MH, Vidal R, Richer C, Oualkacha K, Droit A, Sinnett D. (2017). Specific expression of novel long non-coding RNAs in high-hyperdiploid childhood acute lymphoblastic leukemia. PLoS One12(3):e0174124. doi: 10.1371/journal.pone.0174124


[14] Turgeon M, Oualkacha K, Ciampi A, Miftah H, Dehghan G, Zanke BW, Benedet AL, Rosa-Neto P, Greenwood CMT, Labbe A; Alzheimer’s Disease Neuroimaging Initiative (2016). Principal component of explained variance: An efficient and optimal data dimension reduction framework for association studies. Statistical Methods in Medical Researchdoi:10.1177/0962280216660128.

[13] Mkhadri A., Ouhourane, M.Oualkacha, K. (2016). A coordinate descent algorithm for computing penalized smooth quantile regression.  Statistics and Computingdoi:10.1007/s11222-016-9659-9.

[12] Sun, J.Oualkacha, K., Forgetta, V., Zheng, H.-F., Richards, J.B., Ciampi, A., Greenwood, C.M.T., UK10K Consortium (2016). A method for analyzing multiple continuous phenotypes in rare variant association studies allowing for flexible correlations in variant effects. European Journal of Human Genetics, doi: 10.1038/ejhg.2016.8.

[11] Oualkacha, K., Lakhal-Chaieb, L, Greenwood, C.M.T. (2016). RVPedigree: a suite of family-based rare variant association tests for normally and non-normally distributed quantitative traits.  International Journal of Epidemiology, doi: 10.1093/ije/dyw047.

[10] Kathleen Oros Klein, Karim OualkachaMarie-Hélène Lafond, Sahir Bhatnagar, Patricia N. Tonin and Celia M.T. Greenwood (2016). Gene Coexpression Analyses Differentiate Networks Associated with Diverse Cancers Harboring TP53 Missense or Null Mutations. Frontiers in Genetics-Statistical Genetics and Methodology, doi: 10.3389/fgene.2016.00137.

[9] Sun, J., Bhatnagar, S., Oualkacha, K., Ciampi, A., Greenwood, C.M.T. (2015). Joint analysis of multiple blood pressure phenotypes in GAW19 data by using a multivariate rare-variant association test. BMC Proceedings10(Suppl 7):309-313.


[8] Lakhal-Chaieb L., Oualkacha, K., Richard, B.J., Greenwood, C.M.T. A rare variant association test in family-based designs and non-normal quantitative traits. Statistics in Medicine, 35 (6).

[7] The UK10K Consortium (including Oualkacha, K.) (2015). The UK10K project identifies rare variants in health and disease. Nature526, 82-90.

[6] Sun, J., Oualkacha, K., Greenwood, C.M.T. (2015). Multivariate association test for rare variants controlling for cryptic and family relatedness. Annual Meeting of the International-Genetic-Epidemiology-Society (IGES)Volume: 39.


[5] Oualkacha, K., Cingolani, P., Dastani, Z., Li, R., Spector, T. D., Hammond, C. J., Richards, J. B., Ciampi, A. and Greenwood, C. (2013). Adjusted Sequence Kernel Association Test for Rare Variants Controlling for Cryptic and Family Relatedness. Genetic EpidemiologyVolume 37, Issue 4, pages 366–376.

[4] Dufresne, L., Oualkacha, K., Forgetta. V., Greenwood. CMT. (2013). Pathway Analysis for Genetic Association Studies: To Do, or Not To Do? That is the Question. BMC proceedings.


[3] OualkachaK. and Rivest, L. P. (2012). On the estimation of the mean displacement in SE(p). Biometrika,  14 pages, doi: 10.1093/biomet/ass020.

[2] OualkachaK., Labbe, A., Ciampi, A., Roy, M.A. and Maziade, M. (2012). Principal components of heritability for high dimension quantitative traits and general pedigrees. Journal of Statistical Applications in Genetics and Molecular Biology, Volume 11. Issue 2, Article 4.


[1] OualkachaK. and Rivest, L. P. (2009). A new statistical model for random unit vectors. Journal of Multivariate Analysis100, 70-80.